![The BCL-2 inhibitor ABT-199/venetoclax synergizes with proteasome inhibition via transactivation of the MCL-1 antagonist NOXA | Cell Death Discovery The BCL-2 inhibitor ABT-199/venetoclax synergizes with proteasome inhibition via transactivation of the MCL-1 antagonist NOXA | Cell Death Discovery](https://media.springernature.com/full/springer-static/image/art%3A10.1038%2Fs41420-022-01009-1/MediaObjects/41420_2022_1009_Fig1_HTML.png)
The BCL-2 inhibitor ABT-199/venetoclax synergizes with proteasome inhibition via transactivation of the MCL-1 antagonist NOXA | Cell Death Discovery
![Venetoclax (ABT-199): a Selective Inhibitor of B-Cell Lymphoma-2 | Personalized Medicine in Oncology Venetoclax (ABT-199): a Selective Inhibitor of B-Cell Lymphoma-2 | Personalized Medicine in Oncology](http://d2geqc87xuuo99.cloudfront.net/web/PMOMOA1215/p23_fig.png)
Venetoclax (ABT-199): a Selective Inhibitor of B-Cell Lymphoma-2 | Personalized Medicine in Oncology
![PDF] ABT-199 mediated inhibition of BCL-2 as a novel therapeutic strategy in T-cell acute lymphoblastic leukemia. | Semantic Scholar PDF] ABT-199 mediated inhibition of BCL-2 as a novel therapeutic strategy in T-cell acute lymphoblastic leukemia. | Semantic Scholar](https://d3i71xaburhd42.cloudfront.net/fdf95a15ef1cbf1ab603cd15531b69fef7da162f/7-Figure5-1.png)
PDF] ABT-199 mediated inhibition of BCL-2 as a novel therapeutic strategy in T-cell acute lymphoblastic leukemia. | Semantic Scholar
![Updated Results of a Phase I Study of ABT-199 in Patients with Relapsed or Refractory Chronic Lymphocytic Leukemia | Research To Practice Updated Results of a Phase I Study of ABT-199 in Patients with Relapsed or Refractory Chronic Lymphocytic Leukemia | Research To Practice](http://www.researchtopractice.com/sites/default/files/imagecache/slideshow_image/5mjc/slides/2011/5MJCHEM2013/2/3/Slide03.jpg)
Updated Results of a Phase I Study of ABT-199 in Patients with Relapsed or Refractory Chronic Lymphocytic Leukemia | Research To Practice
![Functional evaluation of Bcl2 and BAX mutations. (A) ABT-199 was unable... | Download Scientific Diagram Functional evaluation of Bcl2 and BAX mutations. (A) ABT-199 was unable... | Download Scientific Diagram](https://www.researchgate.net/publication/262017697/figure/fig3/AS:414526777380865@1475842293526/Functional-evaluation-of-Bcl2-and-BAX-mutations-A-ABT-199-was-unable-to-bind-F101C-and.png)
Functional evaluation of Bcl2 and BAX mutations. (A) ABT-199 was unable... | Download Scientific Diagram
![ABT‐199 (Venetoclax), a BH3‐mimetic Bcl‐2 inhibitor, does not cause Ca2+‐signalling dysregulation or toxicity in pancreatic acinar cells - Jakubowska - 2019 - British Journal of Pharmacology - Wiley Online Library ABT‐199 (Venetoclax), a BH3‐mimetic Bcl‐2 inhibitor, does not cause Ca2+‐signalling dysregulation or toxicity in pancreatic acinar cells - Jakubowska - 2019 - British Journal of Pharmacology - Wiley Online Library](https://bpspubs.onlinelibrary.wiley.com/cms/asset/b25d7c23-15d0-4508-b5e8-1e603c516425/bph14505-fig-0005-m.jpg)
ABT‐199 (Venetoclax), a BH3‐mimetic Bcl‐2 inhibitor, does not cause Ca2+‐signalling dysregulation or toxicity in pancreatic acinar cells - Jakubowska - 2019 - British Journal of Pharmacology - Wiley Online Library
![The BCL-2 selective inhibitor ABT-199 sensitizes soft tissue sarcomas to proteasome inhibition by a concerted mechanism requiring BAX and NOXA. - Abstract - Europe PMC The BCL-2 selective inhibitor ABT-199 sensitizes soft tissue sarcomas to proteasome inhibition by a concerted mechanism requiring BAX and NOXA. - Abstract - Europe PMC](https://europepmc.org/articles/PMC7445285/bin/41419_2020_2910_Fig2_HTML.jpg)
The BCL-2 selective inhibitor ABT-199 sensitizes soft tissue sarcomas to proteasome inhibition by a concerted mechanism requiring BAX and NOXA. - Abstract - Europe PMC
![Inhibition of Mcl-1 enhances cell death induced by the Bcl-2-selective inhibitor ABT-199 in acute myeloid leukemia cells | Signal Transduction and Targeted Therapy Inhibition of Mcl-1 enhances cell death induced by the Bcl-2-selective inhibitor ABT-199 in acute myeloid leukemia cells | Signal Transduction and Targeted Therapy](https://media.springernature.com/full/springer-static/image/art%3A10.1038%2Fsigtrans.2017.12/MediaObjects/41392_2017_Article_BFsigtrans201712_Fig1_HTML.jpg)
Inhibition of Mcl-1 enhances cell death induced by the Bcl-2-selective inhibitor ABT-199 in acute myeloid leukemia cells | Signal Transduction and Targeted Therapy
![Frontiers | The Basic Research of the Combinatorial Therapy of ABT-199 and Homoharringtonine on Acute Myeloid Leukemia Frontiers | The Basic Research of the Combinatorial Therapy of ABT-199 and Homoharringtonine on Acute Myeloid Leukemia](https://www.frontiersin.org/files/Articles/692497/fonc-11-692497-HTML-r1/image_m/fonc-11-692497-g001.jpg)
Frontiers | The Basic Research of the Combinatorial Therapy of ABT-199 and Homoharringtonine on Acute Myeloid Leukemia
Resistance to ABT-199 induced by microenvironmental signals in chronic lymphocytic leukemia can be counteracted by CD20 antibodies or kinase inhibitors | Haematologica
![Attacking cancer's Achilles heel: antagonism of anti‐apoptotic BCL‐2 family members - Opferman - 2016 - The FEBS Journal - Wiley Online Library Attacking cancer's Achilles heel: antagonism of anti‐apoptotic BCL‐2 family members - Opferman - 2016 - The FEBS Journal - Wiley Online Library](https://febs.onlinelibrary.wiley.com/cms/asset/b91c9808-7669-4281-9da9-b1993d947d50/febs13472-fig-0006-m.jpg)
Attacking cancer's Achilles heel: antagonism of anti‐apoptotic BCL‐2 family members - Opferman - 2016 - The FEBS Journal - Wiley Online Library
![ABT‐199 (Venetoclax), a BH3‐mimetic Bcl‐2 inhibitor, does not cause Ca2+‐signalling dysregulation or toxicity in pancreatic acinar cells - Jakubowska - 2019 - British Journal of Pharmacology - Wiley Online Library ABT‐199 (Venetoclax), a BH3‐mimetic Bcl‐2 inhibitor, does not cause Ca2+‐signalling dysregulation or toxicity in pancreatic acinar cells - Jakubowska - 2019 - British Journal of Pharmacology - Wiley Online Library](https://bpspubs.onlinelibrary.wiley.com/cms/asset/07c4b635-cd0d-4394-9d65-b4e434bfb2c8/bph14505-fig-0003-m.jpg)